ICCAS OpenIR
Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy
Li, Yawen; Liu, Zitong; Ma, Yufan; Chen, Yuzhi; Ma, Kun; Wang, Xuefei; Zhang, Deqing; Wang, Zhuo
2019-09-01
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume29Issue:38
AbstractSemiconducting polymer nanoparticles (SPNs) have potential in biological applications. While some SPNs have significant photothermal conversion efficiencies (PCEs) as photothermal and photoacoustic agents, other SPNs offer high fluorescence yields as photoluminescent agents. However, the energy balance distribution in SPNs inhibits their successful applications in photoluminescence/photoacoustic (PL/PA) dual-modality imaging. Additionally, the ultrastability of SPNs in vivo may cause damage to organisms. This work reports nanocomposite semiconducting polymer and tetraphenylethene nanoparticles (STNPs) constructed by semiconducting polymers (SPs) and tetraphenylethene aggregation-induced emission luminogens (TPE AIEgens). The SP SPC10 endows good photothermal conversion ability, and the AIEgen TPBM supports enhanced photoluminescence of the STNPs. The results show that the STNPs can act as PL/PA dual-modality imaging agents. The signal-to-noise (S/N) ratio in the PL modality reaches 8.7, and the imaging depth in the PA modality is 5.8 mm. The SPC10 in the STNPs can be decomposed under 90 mW cm(-2) white light irradiation in 6 h without any other additional agents. Furthermore, the STNPs are sufficient for the treatment of xenograft 4T1 tumor-bearing mice based on photothermal therapy. The nanocomposite STNPs achieve optimized dual-modality PL/PA imaging and the AIEgen-triggered in situ photodegradation of SPNs. These properties indicate the significant potential of STNPs in clinical diagnosis and noninvasive therapy.
DOI10.1002/adfm.201903733
Indexed BySCI
Language英语
WOS IDWOS:000478459800001
EI Accession Number1616-3028
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82725
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Yawen,Liu, Zitong,Ma, Yufan,et al. Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(38).
APA Li, Yawen.,Liu, Zitong.,Ma, Yufan.,Chen, Yuzhi.,Ma, Kun.,...&Wang, Zhuo.(2019).Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy.ADVANCED FUNCTIONAL MATERIALS,29(38).
MLA Li, Yawen,et al."Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy".ADVANCED FUNCTIONAL MATERIALS 29.38(2019).
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