An Injectable Strong Hydrogel for Bone Reconstruction
Zhao, Yanran; Cui, Zhiyong; Liu, Bingchuan; Xiang, Junfeng; Qiu, Dong; Tian, Yun; Qu, Xiaozhong; Yang, Zhenzhong
AbstractFor treating bone defects in periarticular fractures, there is a lack of biomaterial with injectable characteristics, tough structure, and osteogenic capacity for providing a whole-structure support and osteogenesis in the defect area. An injectable hydrogel is an ideal implant, however is weak as load-bearing scaffolds. Herein, a new strategy, i.e., an in situ formation of "active" composite double network (DN), is raised for the preparation of an injectable strong hydrogel particularly against compression. As a demonstration, 4-carboxyphenylboronic acid grafted poly(vinyl alcohol) (PVA) is crosslinked using calcium ions to provide a tough frame while bioactive glass (BG) microspheres are associated by poly(ethylene glycol) to obtain an interpenetrated inorganic network for reinforcement. The injected PVA/BG DN hydrogel gains compressive strength, modulus, and fracture energy of 34 MPa, 0.8 MPa, and 40 kJ m(-2), respectively. Then, the properties can be "autostrengthened" to 57 MPa, 2 MPa, and 65 kJ m(-2) by mineralization in 14 days. In vivo experiments prove that the injected DN hydrogel is more efficient to treat femoral supracondylar bone defects than the implanted bulk DN gel. The work suggests a facile way to obtain a strong hydrogel with injectability, cytocompatibility, and tailorable functionality.
Indexed BySCI
WOS IDWOS:000478497200001
EI Accession Number2192-2659
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Document Type期刊论文
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yanran,Cui, Zhiyong,Liu, Bingchuan,et al. An Injectable Strong Hydrogel for Bone Reconstruction[J]. ADVANCED HEALTHCARE MATERIALS,2019.
APA Zhao, Yanran.,Cui, Zhiyong.,Liu, Bingchuan.,Xiang, Junfeng.,Qiu, Dong.,...&Yang, Zhenzhong.(2019).An Injectable Strong Hydrogel for Bone Reconstruction.ADVANCED HEALTHCARE MATERIALS.
MLA Zhao, Yanran,et al."An Injectable Strong Hydrogel for Bone Reconstruction".ADVANCED HEALTHCARE MATERIALS (2019).
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