ICCAS OpenIR
Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy
Jiang, Linye; Bai, Haotian; Liu, Libing; Lv, Fengting; Ren, Xueqin; Wang, Shu
2019-07-29
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:31Pages:10660-10665
AbstractPhotodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)-linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof-of-concept to explore smart and multifunctional nanoplatforms for phototherapy.
DOI10.1002/anie.201905884
Indexed BySCI
Language英语
WOS IDWOS:000476919100043
EI Accession Number1521-3773
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82719
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Linye,Bai, Haotian,Liu, Libing,et al. Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(31):10660-10665.
APA Jiang, Linye,Bai, Haotian,Liu, Libing,Lv, Fengting,Ren, Xueqin,&Wang, Shu.(2019).Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(31),10660-10665.
MLA Jiang, Linye,et al."Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.31(2019):10660-10665.
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