ICCAS OpenIR
Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings
Liu, Lili; Qiao, Juan; Zhang, Hongyi; Qi, Li
2019-07-29
Source PublicationJOURNAL OF SEPARATION SCIENCE
ISSN1615-9306
AbstractThis study developed an open-tubular capillary electrochromatography protocol for the analysis of antipyretic analgesic drugs, which used a multifunctional homopolymer as coating. A controlled/living radical polymerization strategy was adopted to obtain poly(N-acryloxysuccinimide) with a tunable chain-length. The homopolymer coating enhanced the separation performance by contributing to the hydrophobic and hydrogen-bonding interactions between the analytes and the homopolymer. The effect of polymer chain-length and buffer pH and concentration on the separation efficiency was evaluated. In this approach, baseline separation of the three test drugs was achieved within 15 min. The repeatability of the prepared homopolymer coating was investigated, with the relative standard deviations < 2.88% observed in intra- and interday runs. Good linearity in the 5-800 mu M range (R-2 >= 0.998) demonstrates that accurate quantitative analysis of real samples was achieved. Moreover, the proposed assay was used to quantify the three drugs (aminopyrine, 4-aminoantipyrine, and phenacetin) in urine samples, achieving recovery rates between 92.1 and 108.7%. This promising methodology may be used for the analysis of drugs in real bio-samples and for the development of unique homopolymer coatings for open-tubular capillary electrochromatography systems.
DOI10.1002/jssc.201900516
Indexed BySCI
Language英语
WOS IDWOS:000479555900001
EI Accession Number1615-9314
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82717
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Lili,Qiao, Juan,Zhang, Hongyi,et al. Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings[J]. JOURNAL OF SEPARATION SCIENCE,2019.
APA Liu, Lili,Qiao, Juan,Zhang, Hongyi,&Qi, Li.(2019).Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings.JOURNAL OF SEPARATION SCIENCE.
MLA Liu, Lili,et al."Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings".JOURNAL OF SEPARATION SCIENCE (2019).
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