ICCAS OpenIR
Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery
Wang, Yaqiang; Huang, Da; Wang, Xing; Yang, Fei; Shen, Hong; Wu, Decheng
2019-08-01
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume7Issue:8Pages:3238-3248
AbstractDendrimer micelles are considered to be the most promising synthetic macromolecules for biomedical applications, but their instability in the blood circulation and undesired release at a non-targeted location have become the major concerns for recent research. Herein, zwitterionic sulfobetaine (SB) functionalized polyacetal dendrimers were fabricated through the alternant aza-Michael addition and thiol-ene click reactions. On account of the acid-labile characteristics of acetal segments and charge reversal effects of sulfobetaine moieties, these uniform dendrimers could form biocompatible and biodegradable micelles in aqueous solutions, which present excellent structural stability, good resistivity to protein absorption and high internalization efficiency for a long period. More importantly, effected by the charge shielding of zwitterions on the surface of polyacetal dendrimers, these DOX-loaded nanoparticles exhibited extremely significant pH-responsive drug release behaviors and remarkable anticancer activity. Thus, we believe that this work not only sheds new light on the application of polyacetal dendrimers but also paves a better way for the development of robust on-demand anti-cancer nanosystems with significant potential for clinical translation.
DOI10.1039/c9bm00606k
Indexed BySCI
Language英语
WOS IDWOS:000476955100012
EI Accession Number2047-4849
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82705
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yaqiang,Huang, Da,Wang, Xing,et al. Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery[J]. BIOMATERIALS SCIENCE,2019,7(8):3238-3248.
APA Wang, Yaqiang,Huang, Da,Wang, Xing,Yang, Fei,Shen, Hong,&Wu, Decheng.(2019).Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery.BIOMATERIALS SCIENCE,7(8),3238-3248.
MLA Wang, Yaqiang,et al."Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery".BIOMATERIALS SCIENCE 7.8(2019):3238-3248.
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