ICCAS OpenIR
Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors
Zhang, Peisen; Hou, Yi; Zeng, Jianfeng; Li, Yingying; Wang, Zihua; Zhu, Ran; Ma, Tiancong; Gao, Mingyuan
2019-08-05
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:32Pages:11088-11096
AbstractExogenous Fe-III can be used for cancer magnetic resonance (MR) imaging and potentially for cancer treatment by a ferroptosis pathway or photothermal ablation. To achieve this, effective and accurate delivery of Fe-III to cancerous sites is critical, requiring a balance of release kinetics of Fe3+ in tumorous and normal tissues. A nanoprobe is described consisting of upconversion luminescence (UCL) nanoparticles as a core and a coordinatively unsaturated Fe-III-containing Fe3+/gallic acid complex as a shell. Owing to the introduction of an unsaturated coordination structure, Fe-III in the nanoprobe can be released only in the tumor microenvironment in response to the lightly acidic pH. The multiple UCLs are used for quantitatively visualizing the release of Fe3+ in vivo, whilst the release resultant serves as a photothermal agent. This nanoprobe exhibited ligand-free tumor targeting ability, activatable MR imaging performance, and efficacious therapeutic effects against tumors in vivo.
DOI10.1002/anie.201904880
Indexed BySCI
Language英语
WOS IDWOS:000478635100055
EI Accession Number1521-3773
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82682
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Peisen,Hou, Yi,Zeng, Jianfeng,et al. Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(32):11088-11096.
APA Zhang, Peisen.,Hou, Yi.,Zeng, Jianfeng.,Li, Yingying.,Wang, Zihua.,...&Gao, Mingyuan.(2019).Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(32),11088-11096.
MLA Zhang, Peisen,et al."Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.32(2019):11088-11096.
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