ICCAS OpenIR
MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy
Ding, Binbin; Shao, Shuai; Xiao, Haihua; Sun, Chunqiang; Cai, Xuechao; Jiang, Fan; Zhao, Xueyan; Ma, Ping'an; Lin, Jun
2019-08-21
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:31Pages:14654-14667
AbstractThe limited light penetration depth and tumor hypoxia are two natural shortcomings of photodynamic therapy (PDT). Overcoming these two issues within a single system is still a great challenge. Herein, photosensitizer (PS)-loaded and PEG-modified MnFe2O4-decorated large-pore mesoporous silica-coated beta-NaYF4:20%Yb,2%Er@beta-NaYF4 upconversion nanoparticles (UCMnFe-PS-PEG) as excellent PDT agents are successfully prepared for NIR light-mediated and O-2 self-sufficient PDT. The large mesoporous structure observably increases PS loading efficiency (11.33 wt%) and the green luminescence from upconversion nanoparticles activated by NIR is able to activate PSs to generate ROS effectively. In addition, sub-10 nm MnFe2O4 nanoparticles work as a Fenton catalyst to generate O(2)in situ. In vivo experiments further prove that UCMnFe-PS-PEG not only provides magnetic guidance to the tumor, but also overcomes tumor hypoxia and dramatically enhances PDT efficiency. Furthermore, in vivo MR and UCL imaging are performed for accurate cancer therapy. We believe that the successful construction of the multifunctional UCMnFe-PS-PEG provides more revelations for developing advanced nano-drug systems for cancer therapy.
DOI10.1039/c9nr04858h
Indexed BySCI
Language英语
WOS IDWOS:000484297400013
EI Accession Number2040-3372
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82642
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ding, Binbin,Shao, Shuai,Xiao, Haihua,et al. MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy[J]. NANOSCALE,2019,11(31):14654-14667.
APA Ding, Binbin.,Shao, Shuai.,Xiao, Haihua.,Sun, Chunqiang.,Cai, Xuechao.,...&Lin, Jun.(2019).MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy.NANOSCALE,11(31),14654-14667.
MLA Ding, Binbin,et al."MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy".NANOSCALE 11.31(2019):14654-14667.
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