ICCAS OpenIR
A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery
Wu, Tiantian; Liu, Jianbing; Liu, Manman; Liu, Shaoli; Zhao, Shuai; Tian, Run; Wei, Dengshuai; Liu, Yangzhong; Zhao, Yao; Xiao, Haihua; Ding, Baoquan
2019-09-01
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
AbstractThe targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum-based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double-bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA-based platinum-drug delivery system provides a promising strategy for the treatment of tumors.
DOI10.1002/anie.201909345
Indexed BySCI
Language英语
WOS IDWOS:000483626000001
EI Accession Number1521-3773
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82635
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wu, Tiantian,Liu, Jianbing,Liu, Manman,et al. A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019.
APA Wu, Tiantian.,Liu, Jianbing.,Liu, Manman.,Liu, Shaoli.,Zhao, Shuai.,...&Ding, Baoquan.(2019).A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Wu, Tiantian,et al."A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019).
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