ICCAS OpenIR
D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed
Lan, Weifei; Tan, Qiqi; Qiao, Juan; Shen, Gangyi; Qi, Li
2019-09-01
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume30Issue:9Pages:1627-1630
AbstractWith D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared (D-Pro@AuNCs) within 10 min at 100 degrees C. In the present of gold nanoparticles, the fluorescence of D-Pro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 mu mol/L to 40.0 mu mol/L (R-2 = 0.999) and the limit of detection was 1.9 mu mol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
DOI10.1016/j.cclet.2019.05.019
Indexed BySCI
Language英语
WOS IDWOS:000482530200011
EI Accession Number1878-5964
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82617
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lan, Weifei,Tan, Qiqi,Qiao, Juan,et al. D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed[J]. CHINESE CHEMICAL LETTERS,2019,30(9):1627-1630.
APA Lan, Weifei,Tan, Qiqi,Qiao, Juan,Shen, Gangyi,&Qi, Li.(2019).D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed.CHINESE CHEMICAL LETTERS,30(9),1627-1630.
MLA Lan, Weifei,et al."D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed".CHINESE CHEMICAL LETTERS 30.9(2019):1627-1630.
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