ICCAS OpenIR
Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe
Wang, Yabin; Zhang, Yan; Wang, Zhao; Zhang, Jibin; Qiao, Rui Rui; Xu, Mengqi; Yang, Ning; Gao, Lei; Qiao, Hongyu; Gao, Mingyuan; Cao, Feng
2019-10-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume219
AbstractPro-inflammatory M1 macrophage is identified as a prominent component initializing the progress of vulnerable atherosclerotic plaque. Here, we constructed anti-MARCO NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles (UCNPs) by conjugating polyclonal MARCO antibody to the surface of NaGdF4:Yb,Er@NaGdF4 via condensation reaction. UCNPs displayed highly mono-dispersion with average sizes of 26.7 +/- 0.8 nm and favorable biocompatibility. In vivo upconversion optical imaging revealed that distinctive fluorescence signal could be observed in the regions of carotid artery 10 min post-injection, reached peak value at 1 h and decreased back to baseline at 24 h post-injection. The carotid artery wall demonstrated high signal intensity on T1-weighted MR images after anti-MARCO UCNPs injection, as determined by 7.0T MRI. Immunofluorescence staining of tissue section of carotid artery revealed that MARCO was highly abundant in shoulder regions of plaque. Anti-MARCO UCNPs is a promising optical/MRI dual-modality imaging probe which can non-invasively reflect M1 phenotype macrophages behavior in vivo.
DOI10.1016/j.biomaterials.2019.119378
Indexed BySCI
Language英语
WOS IDWOS:000484648300021
EI Accession Number1878-5905
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82583
Collection中国科学院化学研究所
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yabin,Zhang, Yan,Wang, Zhao,et al. Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe[J]. BIOMATERIALS,2019,219.
APA Wang, Yabin.,Zhang, Yan.,Wang, Zhao.,Zhang, Jibin.,Qiao, Rui Rui.,...&Cao, Feng.(2019).Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe.BIOMATERIALS,219.
MLA Wang, Yabin,et al."Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe".BIOMATERIALS 219(2019).
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