ICCAS OpenIR
In situ investigation of drug diffusion in hydrogels by the refractive index method
Weng, LH; Lu, YS; Shi, LH; Zhang, XM; Zhang, L; Guo, XL; Xu, J
2004-05-15
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume76Issue:10Pages:2807-2812
AbstractThis work describes a simple but novel analytical method for in situ monitoring of the diffusion process of drugs in hydrogels based on refractive index measurements. The diffusion process was monitored by recording the refraction of a laser beam passing through a triangular cell, which allows the determination of changes in the refractive index distribution from the deviated distance of the linear beam. Compared to conventional methods, this new method exhibits advantages such as more simplicity, lower cost, and speed. Further, the refractive index method permits the determination of the concentration distribution of solutes in the hydrogels at any time during the diffusion process under nondestructive circumstances. The precision was determined by successfully applying this new method to the diffusion of a typical antibiotic drug, cefazolin sodium, in agarose gels of various concentrations. By employing Fick's second law, the diffusion behavior was investigated and the diffusion coefficients of cefazolin sodium in agarose gels were therefore obtained. Amsden's physical model based on obstruction effect was applied to the simulation of the diffusion process of cefazolin sodium and turned out to fit the results quite well.
DOI10.1021/ac049975i
Indexed BySCI
Language英语
WOS IDWOS:000221463500018
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82556
Collection中国科学院化学研究所
Corresponding AuthorXu, J
Affiliation1.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100080, Peoples R China
3.Zhejiang Univ, Dept Informat & Elect Engn, Hangzhou 310027, Peoples R China
Recommended Citation
GB/T 7714
Weng, LH,Lu, YS,Shi, LH,et al. In situ investigation of drug diffusion in hydrogels by the refractive index method[J]. ANALYTICAL CHEMISTRY,2004,76(10):2807-2812.
APA Weng, LH.,Lu, YS.,Shi, LH.,Zhang, XM.,Zhang, L.,...&Xu, J.(2004).In situ investigation of drug diffusion in hydrogels by the refractive index method.ANALYTICAL CHEMISTRY,76(10),2807-2812.
MLA Weng, LH,et al."In situ investigation of drug diffusion in hydrogels by the refractive index method".ANALYTICAL CHEMISTRY 76.10(2004):2807-2812.
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