ICCAS OpenIR
Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique
Zhao, YY; Yang, GL; Yan, HY; Yu, Q; Chen, Y
2004-04-01
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume32Issue:4Pages:485-488
AbstractA method for the electrmination of trace ciprofloxacin in plasma was established by the micelle capillary electrophoresis on-line sweeping enrichment technique. The effect of pH in background solution, the concentration of sodium dodecyl sulfate (SDS), injection time, plasma sample pretreatment method on the enrichment of ciprofloxacin was investigated. The experiments were carried out in an uncoated fused silica capillary (55 cm x 75 mum i.d., effective length 47 cm) under the following conditions: background solution of 30 mmol/L borate and 80 mmol/L SDS (pH 9.40); detection wavelength 254 nm; run voltage 18 kV. The plasma sample was directly injected into the column after it was simply deproteinized with acetonitrile. Up to 600-fold concentration of the ciprofloxacin can be enriched. The good linear relation was obtained (r = 0.999, n = 8) in range of 0.04 similar to 10 mg/L. The detection limit was 0.01 mg/L, this method has been applied successfully to determine trace drugs in clinical analysis.
KeywordMicelle Capillary Electrophoresis On-line Sweeping Concentration Technique Drug Concentration In Blood Ciprofloxacin
Indexed BySCI
Language英语
WOS IDWOS:000221218100016
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82524
Collection中国科学院化学研究所
Corresponding AuthorZhao, YY
Affiliation1.Hebei Med Coll Continuing Educ, Expt Ctr, Baoding 071000, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071000, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhao, YY,Yang, GL,Yan, HY,et al. Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(4):485-488.
APA Zhao, YY,Yang, GL,Yan, HY,Yu, Q,&Chen, Y.(2004).Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,32(4),485-488.
MLA Zhao, YY,et al."Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 32.4(2004):485-488.
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