ICCAS OpenIR
alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study
Tanaka, Y; Han, HW; Hagishita, T; Fukui, F; Liu, GQ; Ando, S
2004-02-26
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
Volume357Issue:1Pages:9-12
AbstractThe effects of a-sialylcholesterol (alpha-SC), a synthetic ganglioside analogue, on synaptic neurotransmission were studied using in vivo microdialysis technique. Application of ot-SC through a microdialysis probe enhanced high potassium-evoked release of acetylcholine and glutamate in the hippocampal CA3 region of Wistar rats. The experiments using synaptosomes and FM1-43, a fluorescent styryl dye used for studies of neurotransmitter release mechanisms, showed that ot-SC increased depolarization-induced loss of dye but it did not evoke the dye loss at resting condition. These results indicate that alpha-SC promotes a depolarization-induced exocytotic neurotransmitter release in the brain under in vivo conditions. Application of alpha-SC increased the level of glutamate but not that of acetylcholine, suggesting that a-SC affects spontaneous glutamate release and/or transport system at the brain region. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
KeywordAlpha-sialylcholesterol Acetylcholine Glutamate Microdialysis Hippocampus Fmi-43 Synaptosomes Rats
DOI10.1016/j.neulet.2003.11.062
Indexed BySCI
Language英语
WOS IDWOS:000189169800003
PublisherELSEVIER SCI IRELAND LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82202
Collection中国科学院化学研究所
Corresponding AuthorTanaka, Y
Affiliation1.Tokyo Metropolitan Inst Gerontol, Div Neurosci & Brain Funct, Neuronal Funct Res Grp, Itabashi Ku, Tokyo 1730015, Japan
2.Chinese Acad Sci, Inst Chem, Div Analyt Chem Life Sci, Beijing 100080, Peoples R China
3.Japan Sci & Technol Cooperat, Domest Res Fellowship, Kawaguchi, Saitama 3320012, Japan
Recommended Citation
GB/T 7714
Tanaka, Y,Han, HW,Hagishita, T,et al. alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study[J]. NEUROSCIENCE LETTERS,2004,357(1):9-12.
APA Tanaka, Y,Han, HW,Hagishita, T,Fukui, F,Liu, GQ,&Ando, S.(2004).alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study.NEUROSCIENCE LETTERS,357(1),9-12.
MLA Tanaka, Y,et al."alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study".NEUROSCIENCE LETTERS 357.1(2004):9-12.
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