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Fluorescence response of hypocrellin B to the environmental changes in a mimic biological membrane - liposome
Jin, XY; Zhao, YW; Xie, J; Zhao, JQ
2004-08-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume47Issue:4Pages:335-339
AbstractLiposome is well known as not only a drug-delivery system but also a simple model for biological membranes. It was reported that fluorescence properties of hypocrellins were changeable over some extreme pH values. In the current work, the effects of the microenvironments on the fluorescence properties of HB in liposome, including approximately physiological range of pH values pH = 6.0-8.0, concentration of cholesterols and ionic strength of the solution, were studied. It was found that the fluorescence intensity of HB was sensitive to and also regulated by the microenvironments. When concentration of cholesterols and ionic strength keep invariable in PBS solution, there exists the maximum for the fluorescence of HB-liposome at pH 7.4 while the minimum for that of HB at pH 7.0. In addition, when pH value keeps constant (7.2), there exists the maximum at the ionic strength of 0.12 mol/kg while that at the concentration of 6x10(-4) mol/L for cholesterols. On the other hand, in PBS solution, the lower the ionic strength is, the higher the fluorescence intensity is. The environment-sensitive fluorescence may be potentially applicable to probe some specific environmental features in cells or tissues.
KeywordMicroenvironment Hypocrellin b Liposome Fluorescence
DOI10.1360/03yb0190
Indexed BySCI
Language英语
WOS IDWOS:000224391900010
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82182
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, CAS Key Lab Photochem, Beijing 100080, Peoples R China
2.China Univ Geosci, Sch Earth Sci & Resources, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Jin, XY,Zhao, YW,Xie, J,et al. Fluorescence response of hypocrellin B to the environmental changes in a mimic biological membrane - liposome[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2004,47(4):335-339.
APA Jin, XY,Zhao, YW,Xie, J,&Zhao, JQ.(2004).Fluorescence response of hypocrellin B to the environmental changes in a mimic biological membrane - liposome.SCIENCE IN CHINA SERIES B-CHEMISTRY,47(4),335-339.
MLA Jin, XY,et al."Fluorescence response of hypocrellin B to the environmental changes in a mimic biological membrane - liposome".SCIENCE IN CHINA SERIES B-CHEMISTRY 47.4(2004):335-339.
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