ICCAS OpenIR
A novel water-soluble nanoparticles of hypocrellin B and their interaction with a model protein: C-phycocyanin
Zhao, BZ; Xie, H; Zhao, JQ
2004-01-22
Source PublicationBIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
ISSN0304-4165
Volume1670Issue:2Pages:113-120
AbstractA type of novel hypocrellin B gelatin nanoparticles (HB-G-NP), with size of 20-200 nm, was prepared and characterized. The nanoparticles are readily soluble in water or phosphate-buffered saline (PBS). The interaction between HB-G-NP and a fluorescence protein, C-phycocyanin (C-PC) from Spirulina platensis, was studied. It was found that the energy transfer from HB to C-PC was quite efficient, suggesting adsorption of C-PC on surface of the nanoparticles; secondly, the photosensitization of HB resulted in not only the photo-damage of C-PC but also the photobleaching of HB in the presence of oxygen while it did not in the absence of oxygen, suggesting that the movable reactive oxygen species, instead of the immovable anionic radicals of the photosensitizer, should be responsible for the photo-induced processes. Considering the short free diffusion path length of the reactive oxygen species, it can be deduced that smaller or ring-like particles should be more effective for photo-damage of biomolecules or target tissues. (C) 2003 Elsevier B.V. All rights reserved.
KeywordHypocrellin b Gelatin Nanoparticle C-phycocyanin Complex Energy Transfer Reactive Oxygen Species Photo-damage
DOI10.1016/j.bbagen.2003.10.018
Indexed BySCI
Language英语
WOS IDWOS:000188537900003
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/82060
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhao, BZ,Xie, H,Zhao, JQ. A novel water-soluble nanoparticles of hypocrellin B and their interaction with a model protein: C-phycocyanin[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2004,1670(2):113-120.
APA Zhao, BZ,Xie, H,&Zhao, JQ.(2004).A novel water-soluble nanoparticles of hypocrellin B and their interaction with a model protein: C-phycocyanin.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1670(2),113-120.
MLA Zhao, BZ,et al."A novel water-soluble nanoparticles of hypocrellin B and their interaction with a model protein: C-phycocyanin".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1670.2(2004):113-120.
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