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Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)
Deng, MX; Wang, R; Rong, GZ; Sun, JR; Zhang, XF; Chen, XS; Jing, XB
2004-08-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume25Issue:17Pages:3553-3558
AbstractA novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PBLG-PEO-PCL) was synthesized by a new approach in the following three steps: (1) sequential anionic ring opening polymerization (ROP) of ethylene oxide and epsilon-caprolactone with an acetonitrile/potassium naphthalene initiator system to obtain a diblock copolymer CN-PEO-PCL with a cyano end-group; (2) conversion of the CN end-group into NH2 end-group by hydrogenation to obtain NH2-PEO-PCL; (3) ROP of gamma-benzyl-L-glutamate-N-carboxyanhydrides (Bz-L-GluNCA) with NH2-PEO-PCL as macroinitiator to obtain the target triblock copolymer. The structures from CN-PEO precursor to the triblock copolymers were confirmed by FT-IR and H-1 NMR spectroscopy, and their molecular weights were measured by gel permeation chromatography. The monomer of Bz-L-GluNCA can react almost quantitatively with the amino end-groups of NH2-PEO-PCL macroinitiator by ROP. (C) 2003 Elsevier Ltd. All rights reserved.
KeywordBiodegradation Poly(Epsilon-caprolactone) Poly(Ethylene Oxide) Poly(Gamma-benzyl-l-glutamic Acid) Triblock Copolymer
DOI10.1016/j.biomaterials.2003.10.018
Indexed BySCI
Language英语
WOS IDWOS:000220558200023
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81880
Collection中国科学院化学研究所
Corresponding AuthorChen, XS
AffiliationChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Deng, MX,Wang, R,Rong, GZ,et al. Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)[J]. BIOMATERIALS,2004,25(17):3553-3558.
APA Deng, MX.,Wang, R.,Rong, GZ.,Sun, JR.,Zhang, XF.,...&Jing, XB.(2004).Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone).BIOMATERIALS,25(17),3553-3558.
MLA Deng, MX,et al."Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)".BIOMATERIALS 25.17(2004):3553-3558.
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