ICCAS OpenIR
Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique
Yan, HY; Yang, GL; Qiao, FX; Yi, C
2004-09-21
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
Volume36Issue:1Pages:169-174
AbstractA micellar electrokinetic chromatography (MEKC) method was developed for the determination of nateglinide in animal plasma by on-line sweeping technique, in which plasma samples were simply deproteinized with acetonitrile, and analyzed with 16 mmol/L NaH2PO4 + 6 mmol/L Na2B4O7 + 60 mmol/L sodium dodecyl sulfate (SDS) (pH 7.14) as the running buffer, a fused-silica capillary as the separation tube, 21 kV as the running voltage and UV detection at 214 nm. Under these conditions, more than 100-fold enrichment of nateglinide was obtained with the good linear relation in the range of nateglinide plasma concentration 0.2-7 mg/L (R = 0.998). The method could be applied successfully to determine trace drugs in clinical analysis. (C) 2004 Published by Elsevier B.V.
KeywordMekc On-line Sweeping Nateglinide Plasma
DOI10.1016/j.jpba.2004.05.001
Indexed BySCI
Language英语
WOS IDWOS:000224328000022
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81860
Collection中国科学院化学研究所
Corresponding AuthorYang, GL
Affiliation1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
Recommended Citation
GB/T 7714
Yan, HY,Yang, GL,Qiao, FX,et al. Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2004,36(1):169-174.
APA Yan, HY,Yang, GL,Qiao, FX,&Yi, C.(2004).Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,36(1),169-174.
MLA Yan, HY,et al."Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 36.1(2004):169-174.
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