ICCAS OpenIR
Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase
Zhang, ZF; Yang, GL; Liang, GJ; Liu, HY; Chen, Y
2004-02-18
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
Volume34Issue:3Pages:689-693
AbstractA high-performance liquid chromatographic (HPLC) method was developed for the chiral separation of an antagonist of alpha 1A adrenoceptors, tamsulosin and its S-isomer. Baseline separation of the isomers was achieved within 35 min on a CHIRALCEL OD-RH column with a binary solvent mixture of 50 mmol l(-1) KPF6-acetonitrile (v/v (70:30), pH 5.0) as the optimized mobile phase. The detection limits and quantification limits of both R-isomer and S-isomer were 0.11 and 0.44 ng, respectively. The R.S.D. values of peak-area for the two isomer were 0.42% (of peak-height: 0.77%) for R-isomer and 0.64% (of peak-height:0.92%) for S-isomer (n = 5). (C) 2003 Elsevier B.V. All rights reserved.
KeywordChiral Separation Tamsulosin (5-[(2r)-2-{[2-(2-ethoxyphenoxy) Ethyl] Amino}-propyl]-2-methoxy-benzenesulfonamide) Isomer Cellulose Tris (3 5-dimethylphenylcarbamate) Stationary Phase
DOI10.1016/S0731-7085(03)00555-7
Indexed BySCI
Language英语
WOS IDWOS:000189212100026
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81846
Collection中国科学院化学研究所
Corresponding AuthorYang, GL
Affiliation1.Hebei Univ, Coll Chem & Environm Sci, Dept Chem, Baoding 071002, Hebei, Peoples R China
2.Air Force PLA, Gen Hosp, Beijing 100850, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang, ZF,Yang, GL,Liang, GJ,et al. Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2004,34(3):689-693.
APA Zhang, ZF,Yang, GL,Liang, GJ,Liu, HY,&Chen, Y.(2004).Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,34(3),689-693.
MLA Zhang, ZF,et al."Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 34.3(2004):689-693.
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