ICCAS OpenIR
Molecular recognition in in-situ nateglinide imprinted chiral stationary phase
Yin, JF; Yang, GL; Zhang, YH; Liu, HY; Chen, Y
2004-10-14
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume62Issue:19Pages:1922-1926
AbstractNateglinide has been employed as template for the in-situ preparation of molecularly imprinted continuous rod applied as liquid chromatographic chiral stationary phases for the separation of the enantiomers of the nateglinide. It was shown that the nateglinide-imprinted polymer (nateglinide-MIP) was capable of recognizing the enantiomeric difference of the template and its L-enantiomer, while the non-imprinted polymer had no such ability. The thermodynamic parameters in the chiral separation process were cauculated, and Scatchard analysis was performed to investigate the thermodynamic characteristics and binding characteristics of the nateglinide-MIP stationary phase. The excellent enantioselectivities for the imprinted substance, together with the continuous and homogenous structures of the in-situ MIP, boded well their use as chiral stationary phase.
KeywordMolecularly Imprinted Polymer Chiral Stationary Phase In-situ Polymerization Chiral Separation Nateglinide
Indexed BySCI
Language英语
WOS IDWOS:000224536500013
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81766
Collection中国科学院化学研究所
Corresponding AuthorYin, JF
Affiliation1.Chinese Acad Sci, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
Recommended Citation
GB/T 7714
Yin, JF,Yang, GL,Zhang, YH,et al. Molecular recognition in in-situ nateglinide imprinted chiral stationary phase[J]. ACTA CHIMICA SINICA,2004,62(19):1922-1926.
APA Yin, JF,Yang, GL,Zhang, YH,Liu, HY,&Chen, Y.(2004).Molecular recognition in in-situ nateglinide imprinted chiral stationary phase.ACTA CHIMICA SINICA,62(19),1922-1926.
MLA Yin, JF,et al."Molecular recognition in in-situ nateglinide imprinted chiral stationary phase".ACTA CHIMICA SINICA 62.19(2004):1922-1926.
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