ICCAS OpenIR
Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation
Cai, Q; Bei, JZ; Wang, SG
2004-10-01
Source PublicationACTA POLYMERICA SINICA
ISSN1000-3304
Issue5Pages:719-725
AbstractComb-like biodegradable polylactide-grafted dextran copolymer (Dextran-g-PLA) was synthesized in a bulk lactide polymerization reaction using dextran derivative as macroinitiator and stannous octoate as catalyst. The Dextran-g-PLA copolymers were characterized by H-1-NMR, GPC and intrinsic viscosity measurements, and their molecular architecture was confirmed as PLA segments attached to dextran backbones. Compared to pure PLA, the copolymers showed higher hydrophilicity and faster degradation rate due to the incorporation of hydrophilic glucose units and comb-like structure, which resulted in shortened PLA chain length. This Dextran-g-PLA copolymer was envisioned having good cell affinity and being a good candidate as cell scaffold materials for tissue engineering applications.
KeywordBiodegradable Dextran L-lactide Brush-like Tissue Engineering
Indexed BySCI
Language英语
WOS IDWOS:000224710100019
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81730
Collection中国科学院化学研究所
Corresponding AuthorCai, Q
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Bei, JZ,Wang, SG. Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation[J]. ACTA POLYMERICA SINICA,2004(5):719-725.
APA Cai, Q,Bei, JZ,&Wang, SG.(2004).Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation.ACTA POLYMERICA SINICA(5),719-725.
MLA Cai, Q,et al."Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation".ACTA POLYMERICA SINICA .5(2004):719-725.
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