ICCAS OpenIR
Self-assembly of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) microcapsules for controlled drug release
An, ZH; Lu, G; Mohwald, H; Li, JB
2004-11-19
Source PublicationCHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
Volume10Issue:22Pages:5848-5852
AbstractHuman serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) were applied as a pair to encapsulate ibuprofen microcrystals by means of a technique based on the layer-by-layer (LbL) assembly of oppositely charged species, for the purpose of controlling drug release. The successful adsorption of HSA and DMPA multilayers onto ibuprofen crystals was confirmed by optical microscopy. The drug release process, in a solution of pH 7.4, was monitored by optical microscopy and UV spectroscopy. The results revealed that the rate of release of ibuprofen from HSA/DMPA microcapsules decreased as the capsule wall thickness and drug crystal size increased, indicating that the permeability of the microcapsules can be controlled by simply varying the number of HSA/DMPA deposition cycles.
KeywordControlled Release Lipids Microcapsules Proteins Self-assembly
DOI10.1002/chem.200400090
Indexed BySCI
Language英语
WOS IDWOS:000225141800029
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:62[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81718
Collection中国科学院化学研究所
Corresponding AuthorLi, JB
Affiliation1.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
2.Max Planck Inst Colloids & Interfaces, D-14476 Golm Potsdam, Germany
Recommended Citation
GB/T 7714
An, ZH,Lu, G,Mohwald, H,et al. Self-assembly of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) microcapsules for controlled drug release[J]. CHEMISTRY-A EUROPEAN JOURNAL,2004,10(22):5848-5852.
APA An, ZH,Lu, G,Mohwald, H,&Li, JB.(2004).Self-assembly of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) microcapsules for controlled drug release.CHEMISTRY-A EUROPEAN JOURNAL,10(22),5848-5852.
MLA An, ZH,et al."Self-assembly of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) microcapsules for controlled drug release".CHEMISTRY-A EUROPEAN JOURNAL 10.22(2004):5848-5852.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[An, ZH]'s Articles
[Lu, G]'s Articles
[Mohwald, H]'s Articles
Baidu academic
Similar articles in Baidu academic
[An, ZH]'s Articles
[Lu, G]'s Articles
[Mohwald, H]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[An, ZH]'s Articles
[Lu, G]'s Articles
[Mohwald, H]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.