ICCAS OpenIR
Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters
Yang, YN; Lou, L; Liang, QZ; Chen, XS; Jing, XB
2004
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume25Issue:1Pages:162-165
AbstractMicrospheres containing antiphthisic drug Rifampin were prepared from poly (lactide-co-glycolide) (PLGA) as carrier by emulsion and solvent evaporation method. The conditions of the microsphere preparation such as the drug/carrier molar ratio, the volume ratio of organic solvent to water, PLGA concentration in organic solvent, speed of emulsification, kind of stabilizer, relative molecular weight of PLGA, LLA/GA mass ratio were discussed. The surface morphology of the microspheres in original and degraded states was observed by SEM. The mean diameter and drug content of microspheres were examined, and the drug release in vitro was evaluated. The morphology of the microspheres prepared from PLGA and by 1% gelatin as the stabilizer was integral with 10-30 mum diameter range, 24.3% average drug content, 42-84 d drug-release time. The drug-release kinetics with zero order satisfies the requirements of controlled drug-release.
KeywordRifampin Plga Microspheres Biodegradable Polymer Controlled Drug-release Lung Targcting
Indexed BySCI
Language英语
WOS IDWOS:000188470400041
PublisherHIGHER EDUCATION PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81562
Collection中国科学院化学研究所
Corresponding AuthorChen, XS
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Changchun Univ Technol, Dept Chem Engn, Changchun, Peoples R China
Recommended Citation
GB/T 7714
Yang, YN,Lou, L,Liang, QZ,et al. Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2004,25(1):162-165.
APA Yang, YN,Lou, L,Liang, QZ,Chen, XS,&Jing, XB.(2004).Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,25(1),162-165.
MLA Yang, YN,et al."Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 25.1(2004):162-165.
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