ICCAS OpenIR
Synthesis of new dendritic chiral BINOL ligands and their applications in enantioselective Lewis acid catalyzed addition of diethylzinc to aldehydes
Fan, QH; Yang, XQ; Liu, GG; Chen, XM; Chan, ASC
2003-02-01
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume24Issue:2Pages:274-277
AbstractThe series of new dendritic chiral BINOL ligands(3) were synthesized by condensation reaction of (R)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid(1) and Frechet-type poly(aryl ether) dendrons(2) with an amino group at the focal point in moderate reaction yields. All ligands were characterized by H-1 NMR, IR and MALDI-TOF-MS spectra, which clearly demonstrated the formation of monodispersed dendritic BINOLs. The titanium complexes of these dendritic ligands obtained by mixing(3) with Ti(OPri)(4) in dry toluene were found to be efficient catalysts in asymmetric addition of diethylzinc to aldehydes. The size of the dendritic wedges did not significantly influence the enantioselectivity of the catalyst. Most interestingly, when ortho-chlorobenzaldehyde was used as substrate, we found that enantioselectivity increased slightly with increasing generation of the dendrimers.
KeywordChiral Dendrimer Asymmetric Catalysis 1 1 '-binol
Indexed BySCI
Language英语
WOS IDWOS:000182543000021
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81406
Collection中国科学院化学研究所
Corresponding AuthorFan, QH
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China
3.Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Fan, QH,Yang, XQ,Liu, GG,et al. Synthesis of new dendritic chiral BINOL ligands and their applications in enantioselective Lewis acid catalyzed addition of diethylzinc to aldehydes[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(2):274-277.
APA Fan, QH,Yang, XQ,Liu, GG,Chen, XM,&Chan, ASC.(2003).Synthesis of new dendritic chiral BINOL ligands and their applications in enantioselective Lewis acid catalyzed addition of diethylzinc to aldehydes.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,24(2),274-277.
MLA Fan, QH,et al."Synthesis of new dendritic chiral BINOL ligands and their applications in enantioselective Lewis acid catalyzed addition of diethylzinc to aldehydes".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 24.2(2003):274-277.
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