ICCAS OpenIR
EPR studies of the photodynamic properties of a novel potential photodynamic therapeutic agent: photogeneration of semiquinone radical anion and active oxygen species (O-2(.-), OH., H2O2 and O-1(2))
Xu, SJ; Zhang, XX; Chen, S; Zhang, MH; Shen, T
2003
Source PublicationPHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
ISSN1474-905X
Volume2Issue:8Pages:871-876
AbstractCyclohexylamino-substituted hypocrellin B (CHAHB) has been synthesized with the aim of improving the red absorption and specific affinity for malignant tumors over those of the parent compound. Irradiation of a deoxygenated DMSO solution of CHAHB generates a strong electron paramagnetic resonance (EPR) signal, which is assigned to the semiquinone radical anion of CHAHB with the aid of a series of experimental results. In the presence of oxygen, superoxide radical anions (O-2(.-)) are generated via electron transfer from CHAHB(.-), the precursor, to ground-state molecular oxygen. Hydroxyl radicals were detected by spin-trapping EPR when an oxygen-saturated aqueous solution containing CHAHB and DMPO was irradiated. Singlet oxygen (O-1(2)) is produced via energy transfer from triplet CHAHB to ground-state oxygen molecules, with a sharply decreased quantum yield, i.e. 0.11. Furthermore, cell survival studies reveal CHAHB exhibits much higher photodynamic activities than its parent hypocrellins. The strongly enhanced photodynamic activities and sharply decreased quantum yield of O-1(2) generation suggest that the type I ( free radical) mechanism may play a significant role in CHAHB-PDT, rather than the type II ( singlet oxygen) mechanism found in photofrin-PDT.
DOI10.1039/b303293k
Indexed BySCI
Language英语
WOS IDWOS:000184754600009
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81236
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xu, SJ,Zhang, XX,Chen, S,et al. EPR studies of the photodynamic properties of a novel potential photodynamic therapeutic agent: photogeneration of semiquinone radical anion and active oxygen species (O-2(.-), OH., H2O2 and O-1(2))[J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,2003,2(8):871-876.
APA Xu, SJ,Zhang, XX,Chen, S,Zhang, MH,&Shen, T.(2003).EPR studies of the photodynamic properties of a novel potential photodynamic therapeutic agent: photogeneration of semiquinone radical anion and active oxygen species (O-2(.-), OH., H2O2 and O-1(2)).PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,2(8),871-876.
MLA Xu, SJ,et al."EPR studies of the photodynamic properties of a novel potential photodynamic therapeutic agent: photogeneration of semiquinone radical anion and active oxygen species (O-2(.-), OH., H2O2 and O-1(2))".PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 2.8(2003):871-876.
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