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Studies on the synthesis of two hydrophilic hypocrellin derivatives with enhanced absorption in the red spectral region and on their photogeneration of O-2(center dot-) and O-2((1)Delta(g))
Lee, HY; Chen, S; Zhang, MH; Shen, T
2003-10-15
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume71Issue:1-3Pages:43-50
AbstractTo improve hydrophilicity and photoactivity of the new type of photosensitizer, hypocrellin, two new derivatives were synthesized through a mild reaction method between hypocrellion B (HB) and ethanolamine in tetrahydrofuran (THF) and their molecular structures were characterized by IR, NMR, MS and UV-Vis spectrometry. In the molecular structures of the two derivatives, the peri-hydroxylated perylenquinone structure of the parent HB is preserved and their photoresponses at 600-900 nm (the red spectral region) are enhanced markedly (the molar absorption coefficients at 650 nm for the two new derivatives are EAHB1 log epsilon = 3.72 and EAHB2 log epsilon = 3.91, respectively. In contrast, the parent compound HB exhibits little absorption at 650 nm). Electron paramagnetic resonance (EPR) spin trapping measurement and a 9,10-diphenylanthracene (DPA) bleaching method were employed to investigate the photodynamic action of two chemicals in the presence of oxygen. The quantum yields of O-2((1)Delta(g)) generation of EAHB1 and EAHB2 are 0.08 and 0.45, respectively; the relative quantum yields of (O-2(.1)) generation of EAHB1 and EAHB2 are 0.15 and 0.76, respectively, with the parent compound HB as the standard. 2 (C) 2003 Elsevier B.V. All rights reserved.
KeywordAmino-substituted Hypocrellin b Epr Spectra Photodynamic Therapy Singlet Oxygen Superoxide Anion Radical
DOI10.1016/j.jphotobiol.2003.07.005
Indexed BySCI
Language英语
WOS IDWOS:000185851000006
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81156
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Lee, HY,Chen, S,Zhang, MH,et al. Studies on the synthesis of two hydrophilic hypocrellin derivatives with enhanced absorption in the red spectral region and on their photogeneration of O-2(center dot-) and O-2((1)Delta(g))[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2003,71(1-3):43-50.
APA Lee, HY,Chen, S,Zhang, MH,&Shen, T.(2003).Studies on the synthesis of two hydrophilic hypocrellin derivatives with enhanced absorption in the red spectral region and on their photogeneration of O-2(center dot-) and O-2((1)Delta(g)).JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,71(1-3),43-50.
MLA Lee, HY,et al."Studies on the synthesis of two hydrophilic hypocrellin derivatives with enhanced absorption in the red spectral region and on their photogeneration of O-2(center dot-) and O-2((1)Delta(g))".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 71.1-3(2003):43-50.
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