ICCAS OpenIR
K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)
Zhang, XY; Cao, EH; Zhang, Y; Zhou, CQ; Bai, CL
2003-04-01
Source PublicationJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN0739-1102
Volume20Issue:5Pages:693-701
AbstractThe telomeric DNA oligomers, d(TTAGGG)(n), where n=1, 2, 4, could self-associate into the multi-stranded structures in appropriate condition and exhibited a different CD spectra. The present of Na+ was more advantage to facilitate the formation of anti-parallel conformation, but the present of K+ enhanced their thermal stability. Spectroscopic analysis of 3, 3'-diethyloxadicarbocyanine (DODC) showed the formation of hairpin quadruplex structures for d(TTAGGG)(2) and d(TTAGGG)(4), but d(TTAGGG) could not. The four-stranded tetraplexes and branched nanowire formed in the present of K+ or Na+ alone were observed by atomic force microscopy (AFM). The ability to self-assemble of d(TTAGGG)(n), into four-stranded tetraplexes and nanowires depends strongly on the number of repeating units and ionic environment. A model to explain how these structures formed is proposed.
KeywordTelomeric Dna Nanowire Structure Quadruplex Monovalent Cations Circular Dichroism Atomic Force Microscopy
Indexed BySCI
Language英语
WOS IDWOS:000182182000009
PublisherADENINE PRESS INC
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81090
Collection中国科学院化学研究所
Corresponding AuthorCao, EH
Affiliation1.Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang, XY,Cao, EH,Zhang, Y,et al. K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2003,20(5):693-701.
APA Zhang, XY,Cao, EH,Zhang, Y,Zhou, CQ,&Bai, CL.(2003).K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n).JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,20(5),693-701.
MLA Zhang, XY,et al."K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 20.5(2003):693-701.
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