ICCAS OpenIR
Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC
Yang, GL; Liu, HY; Li, HY; Wang, YH; Li, ZW; Chen, Y
2003-02-01
Source PublicationCHROMATOGRAPHIA
ISSN0009-5893
Volume57Issue:3-4Pages:245-247
AbstractA high-performance liquid chromatographic method is proposed for the simultaneous separation of two pairs of isomers: N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (Nateglinide) and N-(cis-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, trans-4-isopropylcyclohexane-carboxylic acid and cis-4-isopropyl-cyclohexanecarboxylic acid using a C-18 column. The mobile phase is a ternary mixture of acetonitrile-methanol-0.1 M ammonium dihydrogen phosphate buffer, pH 3.0 (5:2:4, v/v/v) and UV detection at 210 nm. Precision, linearity, limit of detection and recovery were also evaluated for each compound. Satisfactory results were obtained.
KeywordColumn Liquid Chromatography Antidiabetic Agent N-(Trans Trans Cis-4-isopropylcyclohexylcarbonyl)-d-phenylalanine Cis-4-isopropylcyclohexanecarboxylic Acid
Indexed BySCI
Language英语
WOS IDWOS:000181318800019
PublisherVIEWEG
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/81074
Collection中国科学院化学研究所
Corresponding AuthorYang, GL
Affiliation1.Hebei Univ, Dept Chem, Baoding 071002, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yang, GL,Liu, HY,Li, HY,et al. Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC[J]. CHROMATOGRAPHIA,2003,57(3-4):245-247.
APA Yang, GL,Liu, HY,Li, HY,Wang, YH,Li, ZW,&Chen, Y.(2003).Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC.CHROMATOGRAPHIA,57(3-4),245-247.
MLA Yang, GL,et al."Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC".CHROMATOGRAPHIA 57.3-4(2003):245-247.
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