ICCAS OpenIR
Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome
Liu, ZD; Wang, DX; Xue, QM; Chen, J; Li, YJ; Bai, XL; Chang, LW
2003-12-01
Source PublicationNUTRITIONAL NEUROSCIENCE
ISSN1028-415X
Volume6Issue:6Pages:389-392
AbstractChronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various systems of whole body. The etiology of CFS remains unclear. Literature reported whether the concentrations of the essential fatty acids in red cell membranes of CFS patients were decreased is controversial. In our study, Forty-two patients who fulfilled the diagnostic criteria defined by Centers for Disease Control and Prevention (CDC). Thirty-seven age- and sex-matched controls were selected from healthy medical staffs and volunteers. After lipid analysis, we found that the levels of the arachidonic acid (ARA) and docosahexanoic acid (DHA) were decreased in patients suffered from CFS. However, the levels of the palmitic acid and oleic acid were increased. We speculated that there are two possible mechanisms-one of which is that oxidative stress has led to an excessive oxidation and resulting in the above fatty acids. Alternatively, insufficiency of ingestion of fatty acids might not be the major cause.
KeywordChronic Fatigue Syndrome Erythrocyte Membrane Fatty Acid Gas Chromatography
DOI10.1080/10284150310001640356
Indexed BySCI
Language英语
WOS IDWOS:000188240900008
PublisherTAYLOR & FRANCIS LTD
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80902
Collection中国科学院化学研究所
Corresponding AuthorLiu, ZD
Affiliation1.Capital Univ Med Sci, Affiliated Hosp, Beijing Friendship Hosp, Dept Neurol, Beijing 100050, Peoples R China
2.Beijing Kuangwuju Hosp, Dept Neurol, Beijing, Peoples R China
3.Acad Sinica, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, ZD,Wang, DX,Xue, QM,et al. Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome[J]. NUTRITIONAL NEUROSCIENCE,2003,6(6):389-392.
APA Liu, ZD.,Wang, DX.,Xue, QM.,Chen, J.,Li, YJ.,...&Chang, LW.(2003).Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome.NUTRITIONAL NEUROSCIENCE,6(6),389-392.
MLA Liu, ZD,et al."Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome".NUTRITIONAL NEUROSCIENCE 6.6(2003):389-392.
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