ICCAS OpenIR
Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)
Zhao, H; Dai, DS; Li, JR; Chen, Y; Jiang, L
2003-12-12
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
Volume312Issue:2Pages:351-354
AbstractThe interaction of poly(allylamine hydrochloride) (PAH) with TAR RNA has been studied by quartz crystal microbalance (QCM) cooperating with capillary electrophoresis (CE). Experimental results showed that PAH had high affinity for TAR RNA. In particular, PAH could disrupt the interaction of Tat peptide with TAR RNA, which is critical for HIV-1 virus replication. The approaches described here indicate that they are powerful for studying the binding processes of Tat peptide-TAR RNA and drug-TAR RNA, having great significance for the design of new drug. (C) 2003 Elsevier Inc. All rights reserved.
KeywordTar Rna Tat Peptide Quartz Crystal Microbalance Capillary Electrophoresis
DOI10.1016/j.bbrc.2003.10.134
Indexed BySCI
Language英语
WOS IDWOS:000186987000013
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80860
Collection中国科学院化学研究所
Corresponding AuthorChen, Y
AffiliationChinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhao, H,Dai, DS,Li, JR,et al. Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003,312(2):351-354.
APA Zhao, H,Dai, DS,Li, JR,Chen, Y,&Jiang, L.(2003).Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride).BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,312(2),351-354.
MLA Zhao, H,et al."Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 312.2(2003):351-354.
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