ICCAS OpenIR
Enzymatic degradation behavior and mechanism of poly(lactide-co-glycolide) foams by trypsin
Cai, Q; Shi, GX; Bei, JZ; Wang, SG
2003-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume24Issue:4Pages:629-638
AbstractThe purpose of this study is to investigate the enzymatic degradation behaviors of porous poly(lactide-co-glycolide) (PLGA) foams in the presence of trypsin, in comparison with their hydrolytic degradation. To inspect the effect of trypsin oil tile degradation of PLGA, both the hydrolytic and enzymatic degradation of non-porous PLGA samples were also performed. The changes of molecular weight and molecular weight distribution (polydispersity) during the degradation were determined by gel permeation chromatograph. And the changes of weight, thickness and morphology with the degradation were also measured. The degradation of PLGA displayed as two stages. In the first stage, the molecular weight of PLGA decreased continuously with degradation time, whereas little weight loss occurred. But in the second stage, the molecular weight of PLGA had decreased to a low value and was almost unchanged with time, while the sample experienced significant weight loss. And it was found that the presence of trypsin could significantly accelerate the weight loss rates of all the PLGA samples, but it Caused little difference in the decrease of molecular weight and the change of PLGA composition between the enzymatic and hydrolytic degradation. Therefore, the enzymatic degradation of PLGA was still primarily a hydrolysis process. A mechanism of enzymatic degradation was proposed that the trypsin could enhance the weight loss of PLGA by acting as surfactant to push the dispersion of degradation products into water even though they could not dissolve in water. (C) 2002 Elsevier Science Ltd. All rights reserved.
KeywordPoly(Lactide-co-glycolidc) Enzymatic Degradation Hydrolytic Degradation Trypsin
Indexed BySCI
Language英语
WOS IDWOS:000179561600011
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80822
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Shi, GX,Bei, JZ,et al. Enzymatic degradation behavior and mechanism of poly(lactide-co-glycolide) foams by trypsin[J]. BIOMATERIALS,2003,24(4):629-638.
APA Cai, Q,Shi, GX,Bei, JZ,&Wang, SG.(2003).Enzymatic degradation behavior and mechanism of poly(lactide-co-glycolide) foams by trypsin.BIOMATERIALS,24(4),629-638.
MLA Cai, Q,et al."Enzymatic degradation behavior and mechanism of poly(lactide-co-glycolide) foams by trypsin".BIOMATERIALS 24.4(2003):629-638.
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