ICCAS OpenIR
Biodegradable electrospun fibers for drug delivery
Jing, Z; Xu, XY; Chen, XS; Liang, QZ; Bian, XC; Yang, LX; Jing, XB
2003-10-30
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume92Issue:3Pages:227-231
AbstractThe influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future. (C) 2003 Elsevier B.V. All rights reserved.
KeywordDrug Delivery Electrospinning Ultrafine Fibers
DOI10.1016/S0168-3659(03)00372-9
Indexed BySCI
Language英语
WOS IDWOS:000186260200001
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:593[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80812
Collection中国科学院化学研究所
Corresponding AuthorJing, XB
AffiliationChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Jing, Z,Xu, XY,Chen, XS,et al. Biodegradable electrospun fibers for drug delivery[J]. JOURNAL OF CONTROLLED RELEASE,2003,92(3):227-231.
APA Jing, Z.,Xu, XY.,Chen, XS.,Liang, QZ.,Bian, XC.,...&Jing, XB.(2003).Biodegradable electrospun fibers for drug delivery.JOURNAL OF CONTROLLED RELEASE,92(3),227-231.
MLA Jing, Z,et al."Biodegradable electrospun fibers for drug delivery".JOURNAL OF CONTROLLED RELEASE 92.3(2003):227-231.
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