ICCAS OpenIR
Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis
Dong, Y; Wang, L; Shangguan, DH; Yu, X; Zhao, R; Han, HW; Liu, GQ
2003-07-01
Source PublicationNEUROCHEMISTRY INTERNATIONAL
ISSN0197-0186
Volume43Issue:1Pages:67-72
AbstractChanges of extracellular glucose and lactate in hippocampus for freely moving rats during the operant conditioned reflex were examined simultaneously. Samples of the dialysate were assayed for both glucose and lactate using in vivo microdialysis and a microbore flow injection analysis-immobilized enzyme reactor-electrochemical detection (FIA-IMER-ECD) system. Microdialysis samplings were conducted in a Skinner box where lights were delivered as conditioned stimuli (CS) paired with foot shocks as unconditioned stimuli (US). In the treatment group the concentration of glucose and lactate showed no fluctuations during the whole process. However, in the control group in which the rats were exposed to many foot shocks, lactate levels decreased by 19% below baseline during the behavioral session and glucose showed a delayed decrease (by 18%). Compared with glucose, lactate can immediately indicate the dynamic changes in brain. (C) 2003 Elsevier Science Ltd. All rights reserved.
KeywordHippocampus Rat Operant Glucose Lactate Microdialysis
Indexed BySCI
Language英语
WOS IDWOS:000181531700007
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80790
Collection中国科学院化学研究所
Corresponding AuthorLiu, GQ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Dong, Y,Wang, L,Shangguan, DH,et al. Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis[J]. NEUROCHEMISTRY INTERNATIONAL,2003,43(1):67-72.
APA Dong, Y.,Wang, L.,Shangguan, DH.,Yu, X.,Zhao, R.,...&Liu, GQ.(2003).Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis.NEUROCHEMISTRY INTERNATIONAL,43(1),67-72.
MLA Dong, Y,et al."Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis".NEUROCHEMISTRY INTERNATIONAL 43.1(2003):67-72.
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