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Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector
Guo, L; Lin, SJ; Yang, YF; Qi, L; Wang, MX; Chen, Y
2003-05-23
Source PublicationJOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
Volume998Issue:1-2Pages:221-228
AbstractNine racemic arylglycine amides were synthesized and successfully enantioseparated by capillary electrophoresis (CE) using highly sulfated beta-cyclodextrin (HS-beta-CD) as a chiral selector. Baseline enantioseparation of the analytes was obtained around neutral pH but not in the acidic conditions that are commonly used. HS-beta-CD content, buffer pH, type and concentration, and organic modifier concentration were studied and optimized for fast and efficient separation. A chiral CE separation system composed of 1.5% (w/v) HS-beta-CD, 0 to 10% (v/v) methanol and 20 mM 3-(N-morpholino)propanesulfonic acid at pH 6.5 was shown suitable for baseline enantioseparation of the mentioned amides within. 6 min, including simultaneous enantioseparation of three positional isomer series (methyl-, methoxyl or chloro-substituted). By using this system, D-enantionters migrated ahead of the L-enantiomers and the enantiomeric resolution order of arylglycine amides was more or less parallel to the pK(a) order of the analytes. (C) 2003 Elsevier Science B.V. All rights reserved.
KeywordEnantiomer Separation Arylglycine Amides Amides Cyclodextrins
DOI10.1016/S0021-9673(03)00653-8
Indexed BySCI
Language英语
WOS IDWOS:000183589100020
PublisherELSEVIER SCIENCE BV
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80628
Collection中国科学院化学研究所
Corresponding AuthorChen, Y
Affiliation1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Biol Chem Lab, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Guo, L,Lin, SJ,Yang, YF,et al. Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector[J]. JOURNAL OF CHROMATOGRAPHY A,2003,998(1-2):221-228.
APA Guo, L,Lin, SJ,Yang, YF,Qi, L,Wang, MX,&Chen, Y.(2003).Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector.JOURNAL OF CHROMATOGRAPHY A,998(1-2),221-228.
MLA Guo, L,et al."Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector".JOURNAL OF CHROMATOGRAPHY A 998.1-2(2003):221-228.
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