ICCAS OpenIR
Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers
Chen, WN; Luo, WJ; Wang, SG; Bei, JZ
2003-03-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume14Issue:3-5Pages:245-253
AbstractA series of multiblock copolymers of PLLA/PEG(PLE) with high molecular weight were synthesized by coupling PLLA-PEG-PLLA triblock copolymers with succinic anhydride in the presence of N-dimethylaminopyridine (DMAP) and dicyclohexylcarbodimide (DCC). The results of the viscometry measurement, GPC and H-1 NMR, elucidated that multiblock PLE copolymers with high content of short PEG segments had been successfully obtained. The thermal properties and the crystallinity were investigated by DSC and X-ray diffraction. Men LA/EG molar ratio and the length of PEG segments were the same in both multiblock and triblock copolymers, multiblock copolymers were less crystalline than the corresponding triblock ones. Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation. In a word, the measurements showed that this multiblock PLE copolymers had high content of short PEG segments (Mn = 2000,4000), high molecular weight (Mw similar to 50000), high hydrophilicity, and good mechanical properties. The drug (5-Fluorourecil) release behavior of these PLE multiblock copolymers had been studied in 0.10 M pH 7.4 phosphate buffer solution (PBS), and the releasing rate could be tailored by adjusting copolymers composition. All of these results indicated that the multiblock PLE copolymers might be useful in medical applications. Copyright (C) 2003 John Wiley Sons, Ltd.
KeywordPoly(L-lactide) Poly(Ethylene Glycol) Multiblock Copolymer Drug-controlled Release 5-fluorourecil
DOI10.1002/pat.301
Indexed ByISTP ; SCI
Language英语
WOS IDWOS:000182654500013
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80552
Collection中国科学院化学研究所
Corresponding AuthorBei, JZ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Chen, WN,Luo, WJ,Wang, SG,et al. Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2003,14(3-5):245-253.
APA Chen, WN,Luo, WJ,Wang, SG,&Bei, JZ.(2003).Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers.POLYMERS FOR ADVANCED TECHNOLOGIES,14(3-5),245-253.
MLA Chen, WN,et al."Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers".POLYMERS FOR ADVANCED TECHNOLOGIES 14.3-5(2003):245-253.
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