ICCAS OpenIR
Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex
Liu, JX; Li, XP; Wang, L; Dong, Y; Han, HW; Liu, GQ
2003
Source PublicationHEARING RESEARCH
ISSN0378-5955
Volume175Issue:1-2Pages:45-53
AbstractIn vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The characterization of neurotransmitters' changes induced by salicylate in the inferior colliculus (IC) and the auditory cortex (AC) may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylate-induced tinnitus. In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.), indicating a salicylate-related increase in regional neuronal activity. The 5-HT level increased to a maximum of 268 +/- 27% basal level in IC 2 It after application and of 277 +/- 24% basal level in AC around 3 h after application. These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation. (C) 2002 Elsevier Science B.V. All rights reserved.
KeywordSalicylate Tinnitus Inferior Colliculus Auditory Cortex 5-ht Microdialysis
Indexed BySCI
Language英语
WOS IDWOS:000180567300005
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80546
Collection中国科学院化学研究所
Corresponding AuthorLiu, JX
Affiliation1.Peking Univ, Dept Otorhinolaryngol, Third Hosp, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, JX,Li, XP,Wang, L,et al. Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex[J]. HEARING RESEARCH,2003,175(1-2):45-53.
APA Liu, JX,Li, XP,Wang, L,Dong, Y,Han, HW,&Liu, GQ.(2003).Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex.HEARING RESEARCH,175(1-2),45-53.
MLA Liu, JX,et al."Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex".HEARING RESEARCH 175.1-2(2003):45-53.
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