ICCAS OpenIR
Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin
Guo, L; Lin, SJ; Dai, DS; Yang, YF; Qi, L; Wang, MX; Chen, Y
2003
Source PublicationANALYTICAL LETTERS
ISSN0003-2719
Volume36Issue:7Pages:1451-1462
AbstractEnantiomers of nine cx-quaternary phenyl amino amides were synthesized and separated for the first time by capillary electrophoresis (CE). Human serum albumin (HSA) was selected as a useful anionic chiral selector by the aid of electrostatic interaction between the anionic selector and the cationic solutes. Partial-filling technique and linear polyacrylamide-coated capillaries were employed so that high concentration of HSA could be used to achieve high resolution without the loss of detection sensitivity. HSA concentration and buffer pH were shown critical and have to be optimized. It was found the hindrance effect of substituent played important role in enantioseparation.
KeywordEnantioseparation Alpha-quaternary Amino Amides Capillary Electrophoresis Human Serum Albumin
DOI10.1081/AL-120021099
Indexed BySCI
Language英语
WOS IDWOS:000183390300013
PublisherMARCEL DEKKER INC
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80432
Collection中国科学院化学研究所
Corresponding AuthorChen, Y
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Guo, L,Lin, SJ,Dai, DS,et al. Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin[J]. ANALYTICAL LETTERS,2003,36(7):1451-1462.
APA Guo, L.,Lin, SJ.,Dai, DS.,Yang, YF.,Qi, L.,...&Chen, Y.(2003).Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin.ANALYTICAL LETTERS,36(7),1451-1462.
MLA Guo, L,et al."Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin".ANALYTICAL LETTERS 36.7(2003):1451-1462.
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