ICCAS OpenIR
Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B
Xu, SJ; Chen, S; Zhang, MH; Shen, T
2003-12-05
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume72Issue:1-3Pages:61-67
AbstractTwo phenmethylamino hypocrellin B derivatives are novel photodynamic agents synthesized by a mild reaction between hypocrellin B and phemnethylamine. The red absorption of the photosensitizers is enlarged distinctly and the peri-hydroxylated perylenequinone structure of the parent HB is preserved. 9,10-diphenyl-anthracene (DPA) bleaching and electron paramagnetic resonance (EPR) spin trapping techniques were used to study the photodynamic activities of the phenmethylamino hypocrellin B derivatives in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(-)) generated in the process of illumination of the phenmethylamino hypocrellin B in aerobic solution were observed. The photodamage of PMAHBs to MGC803 cancer cells was investigated in vitro. The results in vitro reveal that the phenmethylamino hypocrellin B derivatives show a much less significant decrease in cytotoxicity than that of their parent HB. It exhibits higher selectivity of light-orientation, which can decrease the damage to normal tissues by irradiating the tumor tissues, and so increases the drug safety. (C) 2003 Elsevier B.V. All rights reserved.
KeywordHypocrellins Photodynamic Therapy Active Oxygen Species
DOI10.1016/j.photobiol.2003.09.001
Indexed BySCI
Language英语
WOS IDWOS:000187218900008
PublisherELSEVIER SCIENCE SA
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80354
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Ctr Photochem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xu, SJ,Chen, S,Zhang, MH,et al. Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2003,72(1-3):61-67.
APA Xu, SJ,Chen, S,Zhang, MH,&Shen, T.(2003).Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,72(1-3),61-67.
MLA Xu, SJ,et al."Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 72.1-3(2003):61-67.
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