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Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings
An, HB; Xie, J; Zhao, JQ; Li, ZS
2003-09-01
Source PublicationFREE RADICAL RESEARCH
ISSN1071-5762
Volume37Issue:10Pages:1107-1112
AbstractTo solve the problems faced in clinical use of hypocrellins, a water-soluble preparation of Hypocrellin B (HB), HB-Triton X-100 (TX-100) micelles, was prepared. To evaluate the photodynamic activity, the free radicals ((OH)-O-. and HB .macr ) and singlet oxygen (O-1(2)) generated via photosensitization of the preparation in aqueous solution were detected by using electron paramagnetic resonance (EPR) and spectrophotometric methods. It was observed that O-1(2) was formed with a quantum yield of 0.72, similar to that for HB in organic solvents, further, hydroxyl radicals ((OH)-O-.) could also be efficiently produced by the new preparation, which have never before been detected following HB photoactivities. In addition, the semiquinone anion radicals (HB.-) could also be generated via the self-electron transfer between an excited triplet state and a ground state molecule. The accumulation of HB.- would replace that of (OH)-O-. or O-1(2) with the depletion of oxygen in the system. All these findings suggested that the HB-TX-100 micelles could play the photodynamic action through not only the type I mechanism by free radicals ((OH)-O-., O-2(.-) and HB.-) but also the type II mechanism by singlet oxygen ((1) O-2). It can be concluded further that the new preparation basically maintains the inherent photodynamic activity of HB, or even higher.
KeywordHb-tx-100 Micelles Electron Paramagnetic Resonance Free Radicals Singlet Oxygen Photodynamic Activity
DOI10.1080/10715760310001601056
Indexed BySCI
Language英语
WOS IDWOS:000185386300008
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80340
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China
2.Harbin Engn Univ, Coll Chem Engn, Harbin 150001, Peoples R China
Recommended Citation
GB/T 7714
An, HB,Xie, J,Zhao, JQ,et al. Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings[J]. FREE RADICAL RESEARCH,2003,37(10):1107-1112.
APA An, HB,Xie, J,Zhao, JQ,&Li, ZS.(2003).Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings.FREE RADICAL RESEARCH,37(10),1107-1112.
MLA An, HB,et al."Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings".FREE RADICAL RESEARCH 37.10(2003):1107-1112.
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