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Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer
Cai, Q; Wan, YQ; Bei, JZ; Wang, SG
2003-09-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume24Issue:20Pages:3555-3562
AbstractBrush-like biodegradable polylactide-grafted dextran copolymer (PLA-g-dextran) was by a bulk polymerization reaction using a trimethylsilyl-protected (TMS) dextran as macroinitiator and stannous octoate as catalyst. After the polymerization, the TMS groups could be easily removed by immersing the copolymer in methanol for 48 h. The PLA-g-dextran copolymers were characterized by (1)H NMR, GPC and intrinsic viscosity measurements. Besides, mouse 3T3 fibroblasts were cultured on these copolymeric substrates together with pure polylactide (PLA). Although the copolymers exhibited better hydrophilicity and cell affinity compared to pure PLA because of the incorporation of glucose units and the brush-like architecture, it was found that the cells still could not migrate into the center part of scaffold made of PLA-g-dextran copolymer. In result, PLA-g-dextran copolymers themselves were not an appropriate choice for the cell scaffold material, however, it could be used as compatilizer to ameliorate the compatibility between hydrophilic dextran and hydrophobic PLA due to its amphiphilic structure, which could improve the mechanical properties of PLA/dextran blends by reducing the phase separation between PLA and dextran. Therefore, the PLA/ dextran blends, which had good cell affinity and moderate mechanical strength, might be prospect cell scaffold materials. (C) 2003 Elsevier Science Ltd. All rights reserved.
KeywordPolylactide Dextran Graft Copolymer Compatilizer Cell Scaffold
DOI10.1016/S0142-9612(03)00199-6
Indexed BySCI
Language英语
WOS IDWOS:000183645100020
PublisherELSEVIER SCI LTD
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80300
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
Affiliation1.Chinese Acad Sci, PCLCC, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Wan, YQ,Bei, JZ,et al. Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer[J]. BIOMATERIALS,2003,24(20):3555-3562.
APA Cai, Q,Wan, YQ,Bei, JZ,&Wang, SG.(2003).Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer.BIOMATERIALS,24(20),3555-3562.
MLA Cai, Q,et al."Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer".BIOMATERIALS 24.20(2003):3555-3562.
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