ICCAS OpenIR
Photodynamic activity and potential usability of 14-carboxyl hypocrellin B
Zhao, YW; Xie, J; Zhao, JQ
2003
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume27Issue:5Pages:880-885
AbstractNot only the photosensitivity properties but also the amphiphilicity ( both hydrophilicity and lipophilicity) are important factors for hypocrellins to be clinically applicable to photodynamic therapy of vas capillary diseases. A chemically modified derivative, 14-carboxyl hypocrellin B (HBO2H), proved to possess far better amphiphilicity than its parent hypocrellin B (HB) and hypocrellin A ( HA). In this paper, the photophysical and photochemical properties of HBO2H were investigated by spectrophotometric methods and electron paramagnetic resonance (EPR) and its photodynamic action on mouse endothelial cells was also confirmed. In oxygen-free DMSO solution, semiquinone anion radicals (HBO2H.-) are photogenerated via electron transfer between the excited triplet HBO2H and electron donors or ground state HBO2H ( Type I mechanism). When oxygen is present, superoxide anion radicals (O-2(.-)) are generated via electron transfer from HBO2H.- to the ground state oxygen molecules. Singlet oxygen (O-1(2)) can be produced via energy transfer from the triplet state HBO2H to the ground state oxygen molecules (Type II mechanism). The quantum yield of singlet oxygen was estimated to be 0.63 in CHCl3 with 0.76 for HB as a reference. Furthermore, investigations on the competition and transformation between O-1(2) and HBO2H.- suggested that the relative importance of Type I and Type II reactions would depend on the oxygen content in the target tissue.
DOI10.1039/b211388k
Indexed BySCI
Language英语
WOS IDWOS:000182568700022
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/80036
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhao, YW,Xie, J,Zhao, JQ. Photodynamic activity and potential usability of 14-carboxyl hypocrellin B[J]. NEW JOURNAL OF CHEMISTRY,2003,27(5):880-885.
APA Zhao, YW,Xie, J,&Zhao, JQ.(2003).Photodynamic activity and potential usability of 14-carboxyl hypocrellin B.NEW JOURNAL OF CHEMISTRY,27(5),880-885.
MLA Zhao, YW,et al."Photodynamic activity and potential usability of 14-carboxyl hypocrellin B".NEW JOURNAL OF CHEMISTRY 27.5(2003):880-885.
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