ICCAS OpenIR
Synthesis and characterization of three novel amphiphilic aminated hypocrellins as photodynamic therapeutic agents
Xu, SJ; Chen, S; Zhang, MH; Shen, T; Zhang, XX; Wang, ZP
2003-10-01
Source PublicationPHOTOCHEMISTRY AND PHOTOBIOLOGY
ISSN0031-8655
Volume78Issue:4Pages:411-415
AbstractTo improve the amphiphilicities and red absorption of the hypocrellins, three novel 2-amino-2-demethoxy-hypocrellins were synthesized by the mild reactions of hypocrellin B with 4-(2-amino-ethyl)morpholine, N,N-dimethylethylenediamine and 1-(2-amino-ethyl)piperazine, respectively. The structures of these derivatives were characterized with proton nuclear magnetic resonance, infrared and mass spectra (MS). The ultraviolet-visible absorption and fluorescence spectra of the derivatives were measured and the new amino-substituted hypocrellins showed strong absorption in the domain of the phototherapeutic window (600-900 nm). Their amphiphilicities evaluated via the partition coefficients between n-octanol and phosphate-buffered saline buffer improved remarkably. Electron paramagnetic resonance spin-trapping measurements were used to investigate the photodynamic action of the three compounds in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(.-)) generated by illuminating the hypocrellin derivatives in aerobic solution were observed.
Indexed BySCI
Language英语
WOS IDWOS:000186085900015
PublisherAMER SOC PHOTOBIOLOGY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79990
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Xu, SJ,Chen, S,Zhang, MH,et al. Synthesis and characterization of three novel amphiphilic aminated hypocrellins as photodynamic therapeutic agents[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2003,78(4):411-415.
APA Xu, SJ,Chen, S,Zhang, MH,Shen, T,Zhang, XX,&Wang, ZP.(2003).Synthesis and characterization of three novel amphiphilic aminated hypocrellins as photodynamic therapeutic agents.PHOTOCHEMISTRY AND PHOTOBIOLOGY,78(4),411-415.
MLA Xu, SJ,et al."Synthesis and characterization of three novel amphiphilic aminated hypocrellins as photodynamic therapeutic agents".PHOTOCHEMISTRY AND PHOTOBIOLOGY 78.4(2003):411-415.
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