ICCAS OpenIR
Enhancing the cell affinity of macroporous poly(L-lactide) cell scaffold by a convenient surface modification method
Yang, J; Wan, YQ; Tu, CF; Cai, Q; Bei, JZ; Wang, SG
2003-12-01
Source PublicationPOLYMER INTERNATIONAL
ISSN0959-8103
Volume52Issue:12Pages:1892-1899
AbstractIn this study, the macroporous poly(L-lactide) (PLLA) cell scaffold was modified for enhancing its cell affinity by an improved surface-treating medium, a mixture of aqueous 0.25 M NaOH/ethanol. Ethanol was applied as a co-treating medium to wet the polylactone and assist the hydroxide nucleophilic attack on the ester bond. Low concentration of NaOH could be applied, severe bulk degradation could be avoided and the residual alkali was easy to remove. Treating time could also be shortened. After treatment under optimal conditions, the surface hydrophilicity and surface energy of PLLA were improved significantly and the surface roughness was also changed. Modification of the spherulite structure on PLLA surface was observed with the treating time using a computer-assisted image analysis system (CAIAS). The results of gel permeation chromatography measurements indicated that only the outer layer of the PLLA was modified and the bulk properties were not altered. Mouse 3T3 fibroblasts culture results indicated that the improved surface-treating medium was effective and convenient for enhancing the cell affinity of PLLA cell scaffold. (C) 2003 Society of Chemical Industry.
KeywordPlla Surface Hydrolysis Cell Affinity Surface Modification Cell Scaffold Tissue Engineering
DOI10.1002/pi.1272
Indexed BySCI
Language英语
WOS IDWOS:000186680300014
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:81[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79894
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Polymer & Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yang, J,Wan, YQ,Tu, CF,et al. Enhancing the cell affinity of macroporous poly(L-lactide) cell scaffold by a convenient surface modification method[J]. POLYMER INTERNATIONAL,2003,52(12):1892-1899.
APA Yang, J,Wan, YQ,Tu, CF,Cai, Q,Bei, JZ,&Wang, SG.(2003).Enhancing the cell affinity of macroporous poly(L-lactide) cell scaffold by a convenient surface modification method.POLYMER INTERNATIONAL,52(12),1892-1899.
MLA Yang, J,et al."Enhancing the cell affinity of macroporous poly(L-lactide) cell scaffold by a convenient surface modification method".POLYMER INTERNATIONAL 52.12(2003):1892-1899.
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