ICCAS OpenIR
Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives
Wang, MX; Feng, GQ; Zheng, QY
2003-06-01
Source PublicationADVANCED SYNTHESIS & CATALYSIS
ISSN1615-4150
Volume345Issue:6-7Pages:695-698
AbstractCatalyzed by Rhodococcus sp. AJ270 microbial cells, trans-2,2-dihalo-3-phenylcyclopropanecarbonitriles and -amides underwent enantioselective hydrolysis under very mild conditions. Both the efficiency and enantioselectivity of the nitrile hydratase and amidase involved in the cells were strongly determined by the nature of the halogen substituent. The synthetic utility of the biocatalytic process was illustrated by an efficient and multigram scale biotransformation and synthesis of enantiopure 2,2-dichloro-3-phenylcyclopropanecarboxylic acid and amide in both enantiomeric forms.
KeywordAmidase Biotransformation Acid Derivatives Enantioselectivity Hydrolysis Kinetic Resolution Nitrile Hydratase Rhodococcus Sp Aj270 2 2-dihalo-3-phenylcyclopropanecarboxylic
DOI10.1002/adsc.200303020
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000183660400011
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79868
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, MX,Feng, GQ,Zheng, QY. Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives[J]. ADVANCED SYNTHESIS & CATALYSIS,2003,345(6-7):695-698.
APA Wang, MX,Feng, GQ,&Zheng, QY.(2003).Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives.ADVANCED SYNTHESIS & CATALYSIS,345(6-7),695-698.
MLA Wang, MX,et al."Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives".ADVANCED SYNTHESIS & CATALYSIS 345.6-7(2003):695-698.
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