ICCAS OpenIR
Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer
Cai, Q; Zhao, YL; Bei, JZ; Xi, F; Wang, SG
2003-05-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume4Issue:3Pages:828-834
AbstractStar-shaped polylactide was synthesized by bulk polymerization of lactide with poly(amidoamine) (PAMAM) dendrimer as initiator, which was marked as PAMAM-g-PLA for simplicity. The nonlinear architecture of PAMAM-g-PLA was confirmed by gel permeation chromatograph, nuclear magnetic resonance, and differential scanning calorimetry analysis. Unlike the linear polylactide (PLA) with similar molecular weight, PAMAM-g-PLA had a higher hydrophilicity and a faster degradation rate because of shortened polymer chains and increased polar terminal endgroups due to its branch structure. The highly branched structure significantly accelerated the release of water-soluble bovine serum albumin from PAMAM-g-PLA microspheres, whereas the linear PLA with similar molecular weight exhibited an initial time lag release. This star polymer may have potential applications for hydrophilic drug delivery in tissue engineering, including growth factor and antibodies to induce tissue regeneration, by adjusting the chain lengths of PLA branches.
DOI10.1021/bm034051a
Indexed BySCI
Language英语
WOS IDWOS:000182933800049
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79784
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, SKLPPC, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Zhao, YL,Bei, JZ,et al. Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer[J]. BIOMACROMOLECULES,2003,4(3):828-834.
APA Cai, Q,Zhao, YL,Bei, JZ,Xi, F,&Wang, SG.(2003).Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer.BIOMACROMOLECULES,4(3),828-834.
MLA Cai, Q,et al."Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer".BIOMACROMOLECULES 4.3(2003):828-834.
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