ICCAS OpenIR
Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives
Xu, SJ; Zhang, XX; Chen, S; Zhang, MH; Shen, T; Wang, ZP
2003-09-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume48Issue:17Pages:1775-1785
AbstractHypocrellins, as a kind of novel phototherapeutic agents, have several advantages over the clinically used hematoporphyrin derivatives, including high-excited triplet state yield, high phototoxicity, low dark toxicity, and rapid metabolism. However, they exhibit little absorption in the photodynamic window (600-900 nm) and are not water soluble, which limits their application in photodynamic therapy. Sulfonated and metal-ioned hypocrellins have been designed and synthesized to improve their water solubility. Unfortunately, the water-soluble derivatives obtained exhibit lower photodynamic activity than the parent hypocrellins. Thiolated and aminated hypocrellins have also been designed and synthesized to enlarge their photoresponse. Among them, the aminated hypocrellins possess the highest photodynamic activity. We recently have further designed and synthesized some amphiphilic aminated hypocrellin derivatives. Thus, not only the photoresponse but also the water solubility is enhanced. The experiments in vitro and in vivo on the derivatives are under way at present.
KeywordPhotodynamic Therapy Epr Hypocrellins Singlet Oxygen Superoxide Anion Radical
DOI10.1360/03wb0002
Indexed BySCI
Language英语
WOS IDWOS:000185748300001
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79688
Collection中国科学院化学研究所
Corresponding AuthorShen, T
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Photochem, Beijing 100080, Peoples R China
2.Harbin Engn Univ, Dept Chem Engn, Harbin 150001, Peoples R China
Recommended Citation
GB/T 7714
Xu, SJ,Zhang, XX,Chen, S,et al. Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives[J]. CHINESE SCIENCE BULLETIN,2003,48(17):1775-1785.
APA Xu, SJ,Zhang, XX,Chen, S,Zhang, MH,Shen, T,&Wang, ZP.(2003).Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives.CHINESE SCIENCE BULLETIN,48(17),1775-1785.
MLA Xu, SJ,et al."Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives".CHINESE SCIENCE BULLETIN 48.17(2003):1775-1785.
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