ICCAS OpenIR
The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation
Tu, CF; Cai, Q; Yang, J; Wan, YQ; Bei, JZ; Wang, S
2003-08-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume14Issue:8Pages:565-573
AbstractIn this article a new technique was developed to fabricate scaffolds with a unique microstructure by solid-liquid separation in combination with particulate-leaching. Firstly, the effects of polymer concentration, quenching temperature on the porous morphology and the mechanical property of obtained scaffolds during solid-liquid separation have been investigated. Then, salt granules as porogen were introduced into the solid-liquid phase separation to produce the unique pore structure of the scaffold. The pore diameter of the scaffold could be controlled with the particulate size and the wall of pores possessed special microstructure, which enhanced the pore interconnectivity. The cell culture results confirmed that a good interconnectivity of the scaffold prepared by the improved solid-liquid separation was useful for nutrition transportation and cell proliferation. Copyright (C) 2003 John Wiley Sons, Ltd.
KeywordPhase Separation Microstructure Polyesters Scaffold Cell Culture
DOI10.1002/pat.370
Indexed BySCI
Language英语
WOS IDWOS:000184725100006
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:77[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79662
Collection中国科学院化学研究所
Corresponding AuthorWang, S
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, PCCL, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Tu, CF,Cai, Q,Yang, J,et al. The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2003,14(8):565-573.
APA Tu, CF,Cai, Q,Yang, J,Wan, YQ,Bei, JZ,&Wang, S.(2003).The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation.POLYMERS FOR ADVANCED TECHNOLOGIES,14(8),565-573.
MLA Tu, CF,et al."The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation".POLYMERS FOR ADVANCED TECHNOLOGIES 14.8(2003):565-573.
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