ICCAS OpenIR
Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM
Wang, ZG; Wan, LJ; Zhou, CQ; Fang, XH; Wang, C; Bai, CL
2003-03-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume48Issue:5Pages:437-440
AbstractThe scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of P-amyloid(1-42)(Abeta42) on the hydrophobic graphite surface. It was found that Abeta42 were preferentially adsorbed on graphite defects such as the edges. Abeta42 peptides self-assembled into intermediate protoribrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation process of P-amyloid.
KeywordSanning Tunneling Microscopy Atomic Force Microscopy Beta-amyloid Fibrillization
Indexed BySCI
Language英语
WOS IDWOS:000181790200006
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79646
Collection中国科学院化学研究所
Corresponding AuthorBai, CL
AffiliationChinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, ZG,Wan, LJ,Zhou, CQ,et al. Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM[J]. CHINESE SCIENCE BULLETIN,2003,48(5):437-440.
APA Wang, ZG,Wan, LJ,Zhou, CQ,Fang, XH,Wang, C,&Bai, CL.(2003).Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM.CHINESE SCIENCE BULLETIN,48(5),437-440.
MLA Wang, ZG,et al."Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM".CHINESE SCIENCE BULLETIN 48.5(2003):437-440.
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