ICCAS OpenIR
Novel ultrasound contrast agents - Biodegradable poly(lactic acid) microcapsules
Wang, SG; Cui, WJ; Li, GM; Cai, Q; Zhi, G; Zhao, YY; Yang, B; Xu, Y
2003-08-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume46Issue:4Pages:371-378
AbstractAs a novel ultrasound diagnostic contrast agent, the preparation, characterization and ultrasound imaging in the body of dog about poly(lactic acid) (PLLA) microcapsules have been studied. The behavior of this kind of contrast agent in the microcirculation was also investigated. Prepared by (water/oil/water) emulsion-solvent evaporation protocol, the PLLA microcapsules with hollow structure can enhance the ultrasound image both in vitro and in vivo, and the enduring time can last as long as 3 h. The microcirculation examination shows that the PLLA microcapsules with a diameter ranging from 2 to 8 mum could pass through the pulmonary capillaries without retention. All the results prove the PLLA microcapsules for potential use for the clinical application.
KeywordPoly(Lactic Acid) Microcapsules Contrast Agent Ultrasound Diagnosis Blood Filters
DOI10.1360/02yb0194
Indexed BySCI
Language英语
WOS IDWOS:000184931000006
PublisherSCIENCE CHINA PRESS
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79638
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Gen Hosp Peoples Liberat Army, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Wang, SG,Cui, WJ,Li, GM,et al. Novel ultrasound contrast agents - Biodegradable poly(lactic acid) microcapsules[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2003,46(4):371-378.
APA Wang, SG.,Cui, WJ.,Li, GM.,Cai, Q.,Zhi, G.,...&Xu, Y.(2003).Novel ultrasound contrast agents - Biodegradable poly(lactic acid) microcapsules.SCIENCE IN CHINA SERIES B-CHEMISTRY,46(4),371-378.
MLA Wang, SG,et al."Novel ultrasound contrast agents - Biodegradable poly(lactic acid) microcapsules".SCIENCE IN CHINA SERIES B-CHEMISTRY 46.4(2003):371-378.
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