ICCAS OpenIR
Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension
Yu, CL; Xu, SJ; Chen, S; Zhang, MH; Shen, T
2002-11-01
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume68Issue:2-3Pages:73-78
AbstractHypocrellin B (HB) is a natural pigment with a promising application in the photodynamic therapy (PDT) for anticancer treatment. The photobleaching of HB in non-polar organic solvents and in liposomes in aqueous solution were investigated by the measurements of absorption spectra, quenching experiments and determination of photoproducts. Control experiments indicated that the sensitizer, oxygen and light were all essential for the photobleaching of HB, which suggested that it was mainly self-sensitized photooxidation. The illumination of HB with visible light in aerobic non-polar' solvent generated singlet oxygen efficiently [Phi(O-1(2))=0.76] which then attacked the sensitizer HB with formation of an endoperoxide product. The endoperoxide of HB was unstable at room temperature and underwent predominantly loss of singlet oxygen with regeneration of parent HB. The singlet oxygen released from the endoperoxide of HB was detected with chemical trapping experiments. When HB was embedded in EPC liposomes, no endoperoxide product and no singlet oxygen release from the photobleaching process of HB were detected. The quenching experiments indicated that the singlet oxygen mechanism (type II) played an important role in the non-polar solvent and the free radical mechanism (type 1) was predominant in liposomal aqueous solution for the photobleaching of HB. (C) 2002 Elsevier Science B.V. All rights reserved.
KeywordHypocrellin b Self-sensitized Photobleaching Singlet Oxygen Superoxide Endoperoxide Free Radical
Indexed BySCI
Language英语
WOS IDWOS:000179892100002
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79502
Collection中国科学院化学研究所
Corresponding AuthorXu, SJ
AffiliationChinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yu, CL,Xu, SJ,Chen, S,et al. Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2002,68(2-3):73-78.
APA Yu, CL,Xu, SJ,Chen, S,Zhang, MH,&Shen, T.(2002).Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,68(2-3),73-78.
MLA Yu, CL,et al."Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 68.2-3(2002):73-78.
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