ICCAS OpenIR
Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres
Li, GM; Cai, Q; Bei, JZ; Wang, SG
2002-09-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume13Issue:9Pages:636-643
AbstractA novel tri-component copolymer, polycaprolactone/ poly(ethylene oxide)/polylactide (PCEL) was synthesized. The effect of the chemical composition on physical properties was investigated by using NMR, differential scanning calorimetry (DSC) and X-ray diffraction. Both the soft segment poly(ethylene oxide) (PEO) and polycaprolactone (PCL) could enhance the mobility of polymer chains and decrease the crystallizability of the copolymers. The polymeric microspheres, which are of interest for drug delivery systems, were prepared using an emulsification-solvent evaporation technique. By scanning electron microscopy (SEM) and atomic force microscopy (AFM), the surface morphology of the microspheres was studied. It was found that the presence of PEO segment could improve the hydrophilicity of the copolymers and the morphology of the polymeric microspheres could be altered by adjusting the chemical composition. The accumulation of PEO segments on the outer surface of the polymeric microspheres was proven by X-ray photoelectron spectroscopy (XPS). It had also been proven that the PCL segment could facilitate the movement of PEO segment to the outer surface. Copyright (C) 2002 John Wiley Sons, Ltd.
KeywordPolycaprolactone/poly(Ethylene Oxide) Polylacticle Tri-component Copolymer Microspheres Morphology Structure Drug Delivery Systems
DOI10.1002/pat.287
Indexed BySCI
Language英语
WOS IDWOS:000178362500003
PublisherJOHN WILEY & SONS LTD
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79304
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Li, GM,Cai, Q,Bei, JZ,et al. Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(9):636-643.
APA Li, GM,Cai, Q,Bei, JZ,&Wang, SG.(2002).Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres.POLYMERS FOR ADVANCED TECHNOLOGIES,13(9),636-643.
MLA Li, GM,et al."Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres".POLYMERS FOR ADVANCED TECHNOLOGIES 13.9(2002):636-643.
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